吸附无细胞百白破联合疫苗接种的不良反应

Adverse reactions of diphtheria, tetanus, and acellular pertusis combined vaccine

目的研究吸附无细胞百白破联合疫苗(DTaP)接种的不良反应。方法观察2012-2017年渭城区DTaP接种人群不良反应发生情况,并比较不同年龄、月份及性别儿童的不良反应发生情况。结果2012-2017年预防接种不良反应发生率呈逐年上升趋势,6年时间内共接种剂次69509次,出现112例一般反应及52例异常反应,合计164例不良反应。<2岁、7~9月是DTaP接种不良反应高发的人群及季节(P<0.05),不良反应占比分别56.10‰、51.22‰;而不同性别人群不良反应发生情况比较,差异无统计学意义(P>0.05)。结论渭城区DTaP接种不良反应近年有增高趋势,<2岁、7~9月是疫苗接种不良反应高发群体及时间,应引起重视并做好应对措施。

Objective To study the adverse reactions of diphtheria, tetanus and acellular pertusis combined vaccine (DTaP). Methods The adverse reactions of DTaP vaccination population in Weicheng district from 2012 to 2017 wre observed, and the adverse reactions of children of different age, month and gender were compared. Results From 2012 to 2017, the incidence of adverse reactions of preventive inoculation showed an increasing trend year by year. During the six-year period, a total of 69 509 times of inoculation were given, 112 cases of general reactions and 52 cases of abnormal reactions occurred, with a total of 164 cases of adverse reactions. Age <2 years old and July-September were the group and seasons with high incidence of adverse reactions after DTaP inoculation (P<0.05), and the proportion of adverse reactions were 56.10‰ and 51.22‰ respectively. However, there was no statistically significant difference in proportion of adverse reactions between different genders (P>0.05). Conclusion Adverse reactions to DTaP vaccination in Weicheng district have been increasing in recent years, and age <2 years old and July-September are the high-incidence group and season of adverse reactions to DTaP vaccination. This situation should be paid attention to and the corresponding measures should be taken well.