依帕司他联合沙格列汀对早期糖尿病肾病患者血糖、血液生化及氧化应激指标水平的影响

Effects of epalrestat combined with saxagliptin on the levels of blood glucose, blood biochemical indexes and oxidative stress indexes in patients with early diabetic nephropathy

目的探索依帕司他联合沙格列汀对早期糖尿病肾病(DN)患者血糖、血液生化及氧化应激指标水平的影响。方法将100例早期DN患者随机分为对照组(50例)和观察组(50例)。对照组采用常规降糖药物治疗,观察组在对照组基础上使用依帕司他联合沙格列汀治疗。比较两组的临床效果。结果治疗后,两组的HbA1c、2 h PBG、FBG、RBP、Cys C、hs-CRP、BUN、MDA及T-AOC水平均降低,SOD水平升高,且观察组优于对照组(P<0.05)。结论对DN患者实施依帕司他联合沙格列汀治疗,效果显著,可改善患者的肾功能,稳定血糖水平。

Objective To explore the effects of epalrestat combined with saxagliptin on the levels of blood glucose, blood biochemical indexes and oxidative stress indexes in patients with early diabetic nephropathy (DN). Methods A total of 100 patients with early DN were randomly divided into control group (50 cases) and observation group (50 cases). The control group was given conventional hypoglycemic drugs, while the observation group was given epalrestat combined with saxagliptin on the basis of the control group. The clinical effects of the two groups were compared. Results After treatment, the levels of HbA1c, 2 h PBG, FBG, RBP, Cys C, hs-CRP, BUN, MDA and T-AOC in both groups decreased, the level of SOD increased, and those in the observation group were better than the control group (P<0.05). Conclusion Epalrestat combined with saxagliptin in the treatment of patients with DN has a significant effect, which can improve renal function and stabilize blood glucose level.