中药熏洗与高锰酸钾熏洗对痔疮术后患者治疗效果的Meta分析

The Efficacy of Herbal Fumigation and Potassium Permanganate Fumigation in Patients after Hemorrhoid Surgery:A Meta Analysis

目的:比较中药熏洗与高锰酸钾熏洗对痔疮术后患者的治疗效果。方法:检索Pubmed、Embase、Cochrane Library、Medline、UpToDate、中国知网、万方及维普数据库,关于中药熏洗与高锰酸钾熏洗对痔疮术后患者治疗的临床随机对照试验(RCTs)。检索时间为建库至2019年4月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Rev Man 5.3软件、Stata 12.0软件及TSA 0.9软件进行Meta分析。结果:共纳入22个RCTs,包括2 298例患者。Meta分析结果显示,痔疮术后中药熏洗的有效率高于高锰酸钾熏洗,差异有统计学意义[OR=4.95,95%CI(3.65,6.73),P<0.000 01];与高锰酸钾熏洗相比,中药熏洗明显减少疼痛评分[SMD=-1.91,95%CI(-2.77,-1.05),P<0.000 1]和缩短伤口愈合时长[MD=-5.77,95%CI(-8.51,-3.03),P<0.000 1]。结论:中药熏洗在提高治疗有效率、缩短伤口愈合时间和减少疼痛方面优于高锰酸钾熏洗。

Objective:To compare the efficacy of herbal fumigation and potassium permanganate fumigation to patients after hemorrhoid surgery.Methods:We searched PubMed,Embase,Cochrane Library,Medline,UpToDate,China National Knowledge Internet,Wanfang and VIP from inception to April 2019.Randomized controlled trials(RCTs)about herbal fumigation and potassium permanganate fumigation in patients after hemorrhoid surgery were searched.Two researchers independently screened literature,extracted data and measured risk of bias.Data was analyzed by Rev Man 5.3,Stata 12.0 and TSA 0.9.Results:A total of 22 RCTs were included,including 2 298 patients.Meta analysis suggested that the efficacy of herbal fumigation was higher than that of potassium permanganate fumigation,with a significant difference[OR=4.95,95%CI(3.65,6.73),P<0.000 01].Comparing to potassium permanganate fumigation,herbal fumigation lowered the pain score[SMD=-1.91,95%CI(-2.77,-1.05),P<0.000 1]and shortened wound healing time[MD=-5.77,95%CI(-8.51,-3.03),P <0.000 1],obviously.Conclusion:Herbal fumigation is superior to potassium permanganate fumigation in improving of treatment efficiency,shortening of wound healing time and reducing of pain.