生物学标记物在AECOPD患者抗生素应用中的作用

Biomarkers for the use of antibiotics in AECOPD patients

急性加重期是慢性阻塞性肺疾病患者反复出现的问题,其导致慢性阻塞性肺疾病患者的病死率不断上升.慢性阻塞性肺疾病急性加重期(A EC O PD)可由细菌、病毒、致敏原、气候变化及污染导致,主要是由细菌感染所致.A EC O PD患者的抗生素的使用一直存在争议.过度使用抗生素不仅增加了患者的负担,而且会增加细菌耐药的风险.为了促进A EC O PD患者抗生素的合理应用,本文就AECOPD患者的生物学标记物与抗生素应用作一综述.

Acute exacerbations are recurrent problems for patients with chronic obstructive pulmonary disease increasing mortality. Acute exacerbation of chronic obstructive pulmonary disease ( AECOPD) can be caused by bacteria, viruses, allergens, climate change and pollution, mainly caused by bacterial infection. Therefore, the use of antibiotics in AECOPD patients has been controversial issue. Overuse of antibiotics results in financially burden and microbial resistance in AECOPD patients. In order to improve the rational use of antibiotics in AECOPD patients, this paper reviews the research on biomarkers and the use of antibiotics in AECOPD patients.