胸腺素β10对肿瘤发生发展的影响及其机制

Effect of thymosin β 10 on tumorigenesis and development and its mechanism

胸腺素β10(Tβ10)作为β胸腺素家族的一员,主要参与细胞内肌动蛋白的隔离。研究表明Tβ10表达改变与乳腺癌、食管癌、肝癌、胆管癌、卵巢癌等恶性肿瘤关系密切。根据癌症类型的不同,Tβ10呈现出不同的表达状态,而且具体作用机制尚未明确。近年来Tβ10在化学疗法中及其在血清中对预测肿瘤患者化疗效果具有重要意义。

As a member of the β-thymosin family, thymosin β 10 (Tβ10) is mainly involved in the isolation of intracellular actin. Studies have shown that the expression change of Tβ10 is closely correlated with breast cancer, esophageal cancer, liver cancer, cholangiocarcinoma, ovarian cancer and other malignant tumors. Tβ10 is expressed in different states according to the type of cancers, and the mechanism is unclear. The recent research of Tβ10 in chemotherapy and serum findings play a significant role in predicting the efficacy of chemotherapy in cancer patients.