急性早幼粒细胞白血病治疗的现状和进展

Current status and progress of the treatment of acute promyelocytic leukemia

急性早幼粒细胞白血病(APL)是急性白血病的一种特殊类型,近几十年来由于蒽环类化疗药物、全反式维甲酸和砷剂的使用,其治愈率得到了明显的提高,现代化的分层治疗进一步提高了疗效并减少了治疗相关不良反应。文章回顾了全反式维甲酸、砷剂进入临床应用的历史,从疾病特征、全反式维甲酸和砷剂的治疗现状、治疗机制及耐药机制等方面作一介绍。

Acute promyelocytic leukemia (APL) is a special type of acute leukemia. The cure rate of APL has been significantly improved in the past decades due to the use of anthracyclines, all-trans retinoic acid and arsenic. Modern stratified treatment of APL further enhances the therapeutic efficacy and reduces the treatment-related toxicity. This article reviews the history of all-trans retinoic acid and arsenic into clinical application, and the characteristics of disease, treatment status of all-trans retinoic acid and arsenic, treatment mechanism and drug resistance mechanism in APL are introduced.