2-苄氧基溴乙烷的合成

Synthesis of Benzyl 2-Bromoethyl Ether

以溴苄和乙二醇为起始原料,经亲核取代、酯化和溴代三步反应合成了芜地溴铵中间体2-苄氧基溴乙烷,总收率77.5%,产品纯度>99.0%,其结构经1H NMR、MS确证.该方法操作简单、无超低温等苛刻反应条件,目标产物不需精馏和柱层析纯化,适合工业化生产.

Benzyl 2-bromoethyl ether was synthesized through a three-step reaction including nucleophilic substitution, esterification and bromination using benzyl bromide and ethylene glycol as the starting materials with an overall yield of 77.5% and a purity of >99%. The structure of the product was characterized by 1H NMR and MS.This synthetic route had the advantages including simple to operate, no ultra-low temperature and other harsh reaction condition. The target product does not require distillation and column chromatography purification, and is more suitable for industrial production.