噻托溴铵对稳定期COPD患者血清HIF-1α及其睡眠质量的影响

Effect of tiotropium on serum hypoxia-inducible factor 1α and sleep quality of patients with stable chronic obstructive pulmonary disease

目的探讨噻托溴铵对稳定期COPD患者血清缺氧诱导因子-1 (HIF-1α)及其睡眠质量的影响。方法选取2016年12月至2017年12月期间本院呼吸内科住院部收治的60例稳定期COPD患者作为研究对象,按照随机原则将患者分为对照组和研究组,每组各30例。对照组采用常规治疗,研究组在对照组基础上采用噻托溴铵治疗。采用双抗体夹心-酶联免疫吸附试验(DAS-ELISA)测定HIF-1α水平。参照匹茨堡睡眠质量指数量表(PSQI)评定睡眠质量。结果治疗前,两组血清HIF-1α水平比较差异无统计学意义(P>0.05),治疗后,两组血清HIF-1α明显低于治疗前,P<0.05,研究组血清HIF-1α明显低于对照组,P<0.05。治疗前,两组PSQI评分比较差异无统计学意义(P>0.05),治疗后,两组上述评分明显低于治疗前,P<0.05,研究组上述评分明显低于对照组,P<0.05。治疗前,两组第1 s用力呼气容积(FEV1)、呼气峰流速值(PEF)、用力肺活量(FVC)和深吸气量(IC)比较差异无统计学意义(P>0.05),治疗后,两组上述指标明显高于治疗前,P<0.05,研究组上述指标明显高于对照组,P<0.05。结论噻托溴铵有助于降低稳定期COPD患者血清HIF-1α水平,改善患者睡眠质量和肺功能。

Objective To study the effect of tiotropium on the serum hypoxia-inducible factor 1α( HIF-1α) and the sleep quality of the patients with stable chronic obstructive pulmonary disease( COPD).Methods A total of 60 patients with stable COPD admitted in the Department of Respiratory Medicine of our hospital during the period of December 2016 and December 2017 were selected as the research objects. The patients were divided into two groups in strict accordance with the random principle,30 cases in each group.The patients in the control group received a conventional treatment and the patients in the study group received tiotropium treatment on the basis of the control group. Serum HIF-1α was detected by double antibody sandwich assay-enzyme-labeled immunosorbent assay( DAS-ELISA). The sleep quality was evaluated by Pittsburgh Sleep Quality Index( PSQI). Results Before treatment,the serum HIF-1α had no statistical significant difference between the two groups( P>0.05). After treatment,the levels of serum HIF-1αin both groups were significantly lower than those before treatment( P<0.05),but the level was significantly lower in the study group than the control group( P<0.05). Before treatment,the PSQI score had no statistical significant difference between the two groups( P > 0. 05). After treatment,the PSQI scores in both groups were significantly lower than those before treatment( P < 0. 05),however,the score was significantly lower in the study group than the control group( P<0.05). Before treatment,the forced expiratory volume in one second( FEV1),the peak expiratory flow( PEF),the forced vital capacity( FVC),and the inspiratory capacity( IC) had no statistical significant difference between the two groups( P > 0. 05). After treatment,the above indicators of the two groups were significantly higher than those before treatment( P<0.05),and they were significantly higher in the study group than the control group( P<0.05). Conclusion Tiotropium can greatly decrease the serum HIF-1α and improve the sleep quality and the lung functions of the patients with stable COPD.