酪酸梭菌活菌散联合人免疫球蛋白治疗重症手足口病患儿的临床效果

Clinical effect of Clostridium Butyricum Powder combined with human immunoglobulin in the treatment of children with severe hand,foot and mouth disease

目的探讨酪酸梭菌活菌散联合人免疫球蛋白治疗重症手足口病(HFMD)患儿的临床效果。方法选取2014年11月~2018年11月吉林大学第一医院收治的重症HFMD患儿123例,按照随机数字表法将其分为对照组(n=61)和研究组(n=62),对照组患儿给予人免疫球蛋白治疗,研究组患儿给予酪酸梭菌活菌散联合人免疫球蛋白治疗。比较两组临床疗效、免疫功能、肠道屏障功能,记录两组患儿治疗期间不良反应情况。结果研究组患儿治疗5d后临床总有效率高于对照组(P<0.05)。两组患儿治疗5d后免疫球蛋白(Ig)A、IgG均较治疗前升高,且研究组高于对照组(P<0.05),IgM较治疗前降低,且研究组低于对照组(P<0.05)。两组患儿治疗5d后二胺氧化酶、D-乳酸、内毒素均较治疗前降低,且研究组低于对照组(P<0.05)。两组患儿不良反应发生率比较差异无统计学意义(P>0.05)。结论酪酸梭菌活菌散联合人免疫球蛋白治疗重症HFMD患儿效果确切,可有效改善患儿免疫功能、肠道屏障功能,具有一定的临床应用价值。

Objective To investigate the clinical effect of Clostridium Butyricum Powder combined with human immunoglobulin in the treatment of children with severe hand, foot and mouth disease (HFMD). Methods A total of 123 children with severe HFMD admitted to the First Hospital of Jilin University from November 2014 to November 2018 were selected, they were divided into control group (n = 61) and research group (n = 62) according to the random number table method. Children in the control group were treated with human immunoglobulin, while children in the research group were treated with Clostridium Butyricum Powder combined with human immunoglobulin. The clinical efficacy, immune function and intestinal barrier of the two groups were compared. The adverse reactions of children in the two groups during the treatment were recorded. Results The total effective rate of the study group was higher than the control group after 5 days of treatment (P < 0.05). Immunoglobulin (Ig) A and IgG in the study group were higher than those in the control group (P < 0.05), and IgM was lower than that in the control group (P < 0.05). After 5 days of treatment, diamine oxidase, D-lactic acid and endotoxin in the two groups were lower than before treatment, and those in the study group were lower than the control group (P < 0.05). There was no statistically difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Clostridium Butyricum Powder combined with human immunoglobulin is effective in the treatment of severe HFMD children. It can effectively improve the immune function and intestinal barrier function of children, it has certain clinical application value.