子宫内膜癌体素内不相干运动与动态增强参数相关性研究

Correlation of parameters of intravoxel motion incoherent and dynamic contrast-enhanced MR imaging in lesion of endometrial cancer

目的:探索子宫内膜癌病灶体素内不相干运动IVIM定量参数与动态增强DCE-MRI定量参数的相关性。方法: 2017年11月-2018年12月,前瞻纳入36例活检病理证实的子宫内膜癌患者行子宫IVIM及DCE扫描。两名放射科医生独立测量病灶最大层面的D、D*、f、TTP、wash-in、wash-out、Ktrans和Kep。计算观察者间组内相关系数评估测量一致性。应用Pearson和Spearman相关性分析评估各项参数的相关性。结果:观察者间测量一致性良好(ICC>0.8)。D与Kep中度正相关,Pearson r =0.410, p =0.013;f与wash-in弱正相关,Pearson r =0.375, p =0.024;f与wash-out中度正相关,Pearson r =0.483, p =0.003;f与TTP弱负相关,Spearman r =-0.326, p =0.049,f×D*与wash-out中度正相关,Spearman r =0.434, p =0.013。结论:子宫内膜癌病灶IVIM参数与DCE各参数间存在相关性,IVIM MR有望不依赖对比剂增强评价病灶血供特征。

Objective: To investigate the correlation between parameters of intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with endometrial cancer. Methods: Between November 2017 and December 2018,36 patients pathologically confirmed of endometrial cancer were included in this prospective study.Pelvic examinations were performed in a 3.0T MR scanner.IVIM parameters (D,D*,and f) and DCE-MRI parameters (time to peak,wash-in,wash-out,Ktrans,and Kep) were blindly measured by two radiologists.The inter-observer inter-class correlation coefficient was calculated.Pearson and Spearman's correlation was performed to evaluate the correlation among these parameters. Results: Excellent agreement was found between two observers (ICC>0.8).Moderate to mild correlations was found between D and Kep (Pearson r =0.410, P =0.013),f and wash-in (Pearson r =0.375, P =0.024),f and wash-out (Pearson r =0.483, P =0.003),f and TTP (Spearman r =-0.326, P =0.049) and f×D* and wash-out (Spearman r =0.434, P =0.013). Conclusion: IVIM perfusion-related parameters demonstrated a moderate-to-mild correlation with DCE-MRI quantitative parameters in endometrial cancer and have the potential to evaluate the blood supply of the lesion.