缓解期抑郁症患者最后通牒博弈中的社会决策行为

Social decision-making behavior in Ultimatum Game of patients with depression in remission stage

目的:比较缓解或部分缓解期抑郁症患者在社会决策行为上和正常对照的差异。方法:纳入缓解或部分缓解期抑郁症患者26例,正常对照28例,采用最后通牒博弈的实验范式,考察患者和正常对照作为回应者对方案的接受率以及作为提议者提出给对手的分配比例。结果:作为回应者,正常对照对来自计算机的极不公平方案的接受率[38.0 (0.0,100.0)%vs.6.5 (0.0,100.0)%]高于来自人类对手的(P <0.05),但患者面对计算机和人类对手时接受率差异无统计学意义。作为提议者,患者提议给对手的比例[(41.5±12.5)%vs.(31.2±8.8)%]高于正常对照(P <0.001)。正常对照提议给人类对手的比例[(33.1±9.8)%vs.(29.3±9.8)%]要高于计算机(P <0.05),但患者面对计算机和人类对手时提议比例差异无统计学意义。结论:缓解或部分缓解期抑郁症患者在最后通牒博弈中提议给对手的比例高于正常对照且不能区分计算机和人类对手。

Objective: To explore the characteristics of social decision-making behavior of patients with major depressive disorder(MDD) in remission or partial remission in a social interaction context.Methods: Total of 26 MDD patients and 28 normal controls were enrolled in this study.Using the Ultimatum Game,we examined the acceptance rate of the responders and the proposed proportion of the proposers and investigated whether MDD could be associated with abnormalities in social decision-making behavior.Results: As responders,there was no significant difference in acceptance rate when facing unfair proposals from computer and human partners in the MDD patients,while the normal controls accepted more extremely unfair proposals from computer partners than those from human partners [38.0(0.0,100.0)% vs.6.5(0.0,100.0)%,P < 0.05].As proposers,the proposed proportions of the MDD patients were higher than those of the normal controls [(41.5 ± 12.5)% vs.(31.2 ±8.8)%,P < 0.001].Additionally,there was no significant difference in proposed proportion when facing computer and human partners in the MDD patients,while the normal controls proposed higher proportion to the human partners than to computer partners [(33.1 ± 9.8)% vs.(29.3 ± 9.8)%,P < 0.05].Conclusion: Patients with depression in remission or partial remission tend to give the opponent more and can’ t distinguish between human and computer opponents in the ultimatum bargaining game.