咀嚼口香糖对原发性肝癌开腹切除患者术后焦虑抑郁作用的开放试验

An open trial of effect of chewing gum on anxiety and depression symptoms in patients with primary hepatocellular carcinoma after laparotomy

目的:探讨咀嚼口香糖对肝癌开腹切除患者术后焦虑抑郁症状的缓解作用。方法:选取肝胆外科行肝癌开腹切除术后患者64例,随机分为咀嚼组(n=32)和对照组(n=32),最终完成研究的患者共60例(每组30例)。咀嚼组在常规术后护理基础上,从术后第1天至第5天,每天8时、14时给予咀嚼无糖木糖醇、冰凉薄荷味口香糖15 min/次,对照组给予常规术后护理。在干预前、干预后(术后第5天)、随访(干预结束后1周)分别用状态焦虑量表(SAI)、抑郁自评量表(SDS)评估两组焦虑抑郁情况。结果:咀嚼组干预后SAI[(37.8±3.3) vs.(49.4±8.3)]、SDS[(38.9±6.8) vs.(48.9±6.3)]评分均低于对照组(P<0.05),两组随访SAI、SDS评分差异均无统计学意义(均P>0.05)。结论:咀嚼口香糖可作为一种改善肝癌开腹切除患者术后焦虑抑郁的方法。

Objective:To explore the effects of chewing gum on anxiety and depression symptoms in patients with primary hepatocellular carcinoma after laparotomy.Methods:Sixty-four patients with hepatocellular carcinoma after laparotomy in the department of hepatobiliary surgery were randomly divided into the chewing group(n=32) and the control group(n=32).A total of 60 patients(each group of 30 cases) completed the study.On the basis of routine postoperative care,the chewing group was given sugar-free xylitol and cold mint-flavored chewing gum for 15 min every day from 8∶00 and 14∶00 on the first day to the fifth day after surgery,while the control group was given routine postoperative care.The state anxiety inventory(SAI) and self-rating depression scale(SDS) were used to evaluate the anxiety and depression of the two groups before intervention,after intervention(5 days after surgery) and follow-up(1 week after intervention).Results:After the intervention,the SAI [(37.8±3.3) vs.(49.4±8.3)] and SDS [(38.9±6.8) vs.(48.9±6.3)] scores were lower in the chewing group than in the control group(P<0.05),while the differences in follow-up SAI and SDS scores between the two groups were not statistically significant(P> 0.05).Conclusion:It suggests that chewing gum could be used as a method to improve anxiety and depression in patients with hepatocellular carcinoma after laparotomy.