胃内微生态与胃部疾病关系的研究进展

Gastric microflora and gastric disease

长期以来,学术界认为胃内是无菌的环境,但1982年幽门螺杆菌(Helicobacter pylori,H.pylori)的发现改变了这一概念.在过去的几十年里,检测方法从传统的细菌培养,到宏基因组高通量测序技术的应用,这些现代技术为洞察胃内的微生物群落、分析群落间的相互作用提供了支持.H.pylori是胃部疾病重要的危险因素,但可能还有别的菌群也参与了胃部疾病的发生.本文就目前有关胃微生物群与胃部疾病的相互关系的研究进展作一综述,旨从微生态角度对胃部疾病的防治策略提供新的思路.

Gastric environment has long been considered sterile,but the discovery of Helicobacter pylori(H.pylori)changed such concept in 1982.Over the past few decades,modern techniques have provided insight into microbial communities in the stomach and the interactions between communities,ranging from methods that rely on bacterial culture to the application of macrogenomics and high-throughput sequencing techniques.H.pylori is an important risk factor for gastric disease,but there may be other bacteria involved in the occurrence of gastric disease.This review summarizes the current progress in the understanding of the relationship between gastric microflora and gastric disease.