摘要
MicroRNA是一种内源性单链非编码小分子RNA,通过与靶mRNA的特异性结合,以降解mRNA或阻碍其翻译从而在转录后水平调节靶mRNA的表达.MicroRNA-146a参与机体的多种生物学过程,具有多种生物学功能.本文将从其控制炎症反应,调节免疫,介导髓样细胞增殖以及肿瘤发生发展等几个方面进行综述.
MicroRNAs are endogenous single-stranded noncoding small RNAs that specifically bind to target mRNAs to degrade mRNAs or hinder their translation to regulate the expression of target mRNAs at the posttranscriptional level.MicroRNA-146a is involved in a bulk of biological processes and has a variety of biological functions.This article will review several aspects of the role of microRNA-146a,including controlling inflammation,regulating immunity,mediating myeloid cell proliferation,and involvement in tumor occurrence and development.
作者
吴慧
范恒
刘星星
Hui Wu;Heng Fan;Xing-Xing Liu(Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei Province,China;Department of Integrated Traditional Chinese and Western Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China)
出处
《世界华人消化杂志》
CAS
2019年第18期1155-1160,共6页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目,No.81503416
国家自然科学基金资助项目,No.81573784~~
