甘肃省地方性氟骨症病人生存质量特征分析

Analysis of characteristics of quality of life in patients with endemic skeletal fluorosis in Gansu province

目的运用标准化量表调查地方性氟骨症病人的生存质量,为制定病人康复治疗策略提供依据。方法选择甘肃省饮水型地方性氟中毒监测县作为调查区域,调查382名地方性氟骨症病人和419名健康人群,采用SF-36量表调查生存质量,从健康状态、年龄、病情等方面分析地方性氟骨症病人生理健康和心理健康的生存质量特征。结果地方性氟骨症病人生理(46.49±16.60)和心理(48.88±18.47)两方面的生存质量平均得分(t=23.414)与健康人群(分别为76.70±19.62,75.81±16.62,t=21.715)相比,差异有统计学意义(均P<0.001),并且各维度的差异有统计学意义(均P<0.001);随着年龄增长,病人的生存质量生理(F=13.250)和心理(F=5.580)两个综合测量指标得分呈现下降趋势(均P<0.001),各维度中,生理机能(PF,F=18.733),生理职能(RP,F=5.216),BP(F=9.718),一般健康状况(GH,F=5.126),精力(VT,F=9.021)和情感职能(RE,F=3.244)6个维度的差异有统计学意义(均P<0.05);随着患病程度的增加,病人的生存质量生理(F=10.664)和心理(F=3.111)两个综合测量指标得分呈现下降趋势(均P<0.05),各维度中,PF(F=20.729),RP(F=6.896),BP(F=7.878),社会功能(SF,F=3.498),RE(F=3.371)和精神健康(MH,F=3.498)6个维度的差异有统计学意义(均P<0.05)。结论通过分析地方性氟骨症病人的生存质量特征,可充分了解病人的病情以及康复需求,为病人治疗和促进功能恢复提供评价依据。

Objective To investigate the quality of life of patients with endemic skeletal fluorosis by standardized scale, and provide evidence for the formulation of patients rehabilitation. Methods Surveillance counties of drinking water endemic fluorosis in Gansu province were selected as the investigated areas, and 382 patients of endemic skeletal fluorosis and 419 healthy people were surveyed. The quality of life was investigated by SF-36 scale. The characteristics of physical and mental health of patients of endemic skeletal fluorosis were analyzed in terms of their health status, age and condition. Results The average scores of physical and psychological quality of life of the patients were 46.49±16.60(t=23.414) and 48.88±18.47(t=23.414), with statistical difference(all P<0.001), compared with those of the healthy people(76.70±19.62 and 75.81±16.62),and there were statistical differences in the scores of various subdivisions(all P<0.001). With the growth of age, the scores of patients’ quality of life in both physiological(F=13.250) and psychological(F=5.580) aspects showed a downward trend(all P<0.001), there were statistical differences(all P<0.05) in some subdivisions for physical functioning(PF, F=18.733), rolephysical(RP, F=5.216), body pain(BP, F=9.718), gneral health(GH, F=5.126), vitality(VT, F=9.021) and roleemotional(RE, F=3.244). In terms of the prevalence, the scores of patients’ quality of life in both physiological(F=10.664)and psychological(F=3.111) aspects showed a downward trend(all P<0.05). There were statistical differences(P<0.05) in some subdivisions for PF(F=20.729), RP(F=6.896), BP(F=7.878), social functioal(SF, F=3.498), RE(F=3.371) and mental health(MH, F=3.498). Conclusions By analyzing the life quality characteristics of patients of endemic skeletal fluorosis,the status and rehabilitation needs of patients can be further understood, and provide evaluation basis for the treatment and promoting functional recovery of patients.