健康儿童中超广谱β-内酰胺酶流行及影响因素分析

Analysis of ESBLs prevalence and its influencing factors in healthy children

目的了解超广谱β-内酰胺酶(extend-spectrum-β-lactamase,ESBLs)在健康儿童中的流行情况并分析其影响因素。方法通过概述文献的方法,分析近年来国内外健康儿童体内携带ESBLs的流行情况及影响因素。结果近年来,多国在研究健康儿童携带ESBLs基因分型中,以CTX-M型酶为主,其中较多文献中出现频次最多的基因型为CTXM-15,其影响因素包括环境、年龄和家庭等。结论大多数研究都集中在住院儿童中携带ESBLs的细菌,但近些年,健康儿童体内携带ESBLs已成为多国研究热点,值得关注。

Objective To understand the prevalence of extend-spectrum-β-lactamase(ESBLs) in healthy children and analyze its influencing factors. Methods The prevalence of ESBLs and its influencing factors in the healthy children at home and abroad were analyzed with literature overview method. Results The CTX-M was the main genotype of ESBLs in healthy children in the studies of many countries in recent years. The frequency of genotype of CTX-M-15 was the most in many literatures, and the influencing factors were environment, age and family, etc. Conclusions The hospitalized children with the bacteria carrying ESBLs had been studied in most researches before. Now, the studies on healthy children with ESBLs have become hot in some countries and that deserves attention.