蒙脱石散联合布拉酵母菌治疗小儿急性胃肠炎的效果及对血清炎症因子的影响

Effect of montmorillonite powder combined with Saccharomyces brasiliensis on acute gastroenteritis in children and its influence on serum inflammatory factors

目的:探讨蒙脱石散联合布拉酵母菌治疗小儿急性胃肠炎的效果及对血清炎症因子的影响.方法:选取2017年6月~2018年7月我院收治的246例急性胃肠炎患儿为研究对象.根据用药方式不同,随机分为对照组(n=123)和观察组(n=123).两组患儿均予以口服补液盐纠正脱水和水电解质紊乱,体温超过38.5℃的患儿予以布洛芬或对乙酰氨基酚退热治疗;在此基础上,对照组患儿给予蒙脱石散治疗,观察组给予蒙脱石散和布拉酵母菌治疗;疗程7 d.比较两组患者治疗效果、临床症状及改善情况、血清炎症因子PCT、IL-6水平变化、不良反应情况.结果:治疗第3d、7d后,观察组大便频次和大便性状评分均明显低于对照组;观察组腹泻持续时间明显短于对照组;治疗后,两组患儿血清降钙素原(PCT)、白细胞介素6(IL-6)水平显著低于治疗前;观察组血清PCT、IL-6水平明显低于对照组;观察组患儿的临床治疗总有效率为94.30%,显著高于对照组的83.73%;两组患儿不良反应比较差异无统计学意义.结论:采用蒙脱石散联合布拉酵母菌治疗小儿急性胃肠炎的临床疗效显著,能够明显改善临床症状,降低血清PCT、IL-6水平,值得临床推广应用.

Objective To investigate the effect of montmorillonite powder combined with Saccharomyces brasiliensis on acute gastroenteritis in children and its influence on serum inflammatory factors. Methods 246 children with acute gastroenteritis admitted to our hospital from June 2017 to July 2018 were selected as the study subjects. They were randomly divided into control group (n=123) and observation group (n=123) according to different medication methods. Both groups were treated with oral rehydration salts to correct dehydration and electrolyte disturbance, and children whose body temperature exceeded 3&5 degrees Celsius were treated with ibuprofen or paracetamol. On this basis, children in the control group were treated with montmorillonite powder, while those in the observation group were treated with montmorillonite powder and Brassica pastoris for 7 days. The therapeutic effect, clinical symptoms and improvement, changes of serum inflammatory factors PCT, IL-6 levels and adverse reactions were compared between the two groups. Results After the 3rd and 7th day of treatment, the frequency of stool and the score of stool characteristics in the observation group were significantly lower than those in the control group. The dura-tion of diarrhea in the observation group was significantly shorter than that in the control group. After treatment, the serum levels of procalcitonin (PCT) and interleukin-6(IL-6) in the two groups were significantly lower than those before treatment. The levels of serum PCT and IL-6 in the observation group were significantly lower than those in the control group. The total effective rate of the observation group was 94.30%, which was significantly higher than 83.73% of the control group. There was no significant difference in adverse reactions between the two groups. Conclusion The clinical effect of montmorillonite powder combined with Saccharomyces brasiliensis in the treatment of acute gastroenteritis in children is remarkable. It can significantly improve clinical symptoms and reduce the levels of PCT and IL-6 in serum, which is worthy of clinical application.