乙酰辅酶A酰基转移酶1基因研究进展

Advance in Acetyl-CoA acyltransferase 1 Gene

乙酰辅酶A酰基转移酶1(ACAA1)基因编码硫解酶家族的酶,属于酰基辅酶A代谢酶超家族中的硫解酶家族。ACAA1分布在过氧化物酶体中,通过催化β-氧化途径的最后一步参与脂肪酸的延伸和降解,是细胞脂代谢过程中一个重要调控基因。本文综述了ACAA1基因的结构、表达、分子机制及其所参与的相关代谢反应。

The acetyl-CoA acyltransferase 1(ACAA1)gene encodes the thiolase family of enzymes,which belongs to the thiolase family of the acyl-CoA metabolic enzyme superfamily.It is distributed in peroxisomes and involved in the extension and degradation of fatty acids by catalyzing the last step of the beta-oxidation pathway;It is an important regulatory gene in the process of cell lipid metabolism.In this article,the structure,expression,molecular mechanisms and related metabolic reactions of the ACAA1 gene were reviewed.