哺乳动物Acot2基因的研究进展

Advances in Mammalian Acot2 Gene

酰基辅酶A硫酯酶2(Acot2)是酰基辅酶A硫酯酶(Acots)家族成员之一,其将酰基辅酶A(CoA)水解成游离脂肪酸和CoA,具有维持细胞水平的游离脂肪酸和酰基CoA(游离脂肪酸的活化形式)的潜力,在脂质代谢中发挥重要作用。本文对Acot2基因的定位、结构特征、生理功能及其调控进行综述,以期对Acot2基因的进一步探究提供参考。

Acyl-CoAthioesterase-2(Acot2)is one of the members of the acyl-CoA thioesterases(Acots)family,which hydrolyzes the acyl-CoA into free fatty acids and CoA,with the potential to maintain cellular levels of free fatty acids and acyl-CoA(activation form of free fatty acids),and plays an important role in lipid metabolism.In this paper,the location,structural characteristics,physiological function and regulation of Acot2 gene are reviewed in order to provide reference for further exploration of Acot2 gene.