关注原发性衰老相关性tau蛋白病

Pay attention to primary age-related tauopathy

原发性衰老相关性tau蛋白病(PART)是一种以大脑中tau蛋白沉积局限于内嗅皮质和海马等部位(Braak分期为0-Ⅳ期)、但没有或仅有极少的β-淀粉样蛋白(Aβ)沉积(Thal Aβ分期为0-2期)为特征的病理改变。近年来,PART在国际上日益受到关注,但其和阿尔茨海默病(AD)的关系仍存在争议。因此,加强临床医生和相关研究人员对PART的认识,对于理解脑老化与AD等认知障碍疾病的关系具有重要意义。

Primary age-related tauopathy (PART) is a type of pathological change characterized by the deposition of tau protein in the brain confined to the entorhinal cortex and hippocampus (Braak stage 0-Ⅳ), with no or little amyloid-β protein (Aβ) deposition (Thal Aβ stage 0-2). In recent years, PART has received lots of attention, but its relationship with Alzheimer's disease (AD) remains controversial. Therefore, strengthening the understanding of PART among clinicians and relevant researchers is of great value in interpretation of the relationship between brain aging and AD as well as other cognitive impairment diseases.