肠微生态移植重建治疗重度银屑病的临床研究

Fecal microbiota transplantation as a novel therapy for severe psoriasis

通过肠微生态移植重建(FMT)治疗重度银屑病,探索治疗银屑病的新方法.患者男,36岁,患寻常型银屑病10年,肠易激综合征15年,进行2次胃、肠镜联合FMT治疗.评估治疗前后皮损累及体表面积(BSA)、银屑病面积和严重程度指数(PASI)、生活质量指数(DLQI)、皮肤组织病理、肠道症状、安全性及血清肿瘤坏死因子α等.结果显示,FMT治疗该例银屑病患者临床疗效显著,肠易激综合征临床症状消失,且无不良反应发生.提示FMT可能是治疗银屑病的一种新疗法,值得进一步研究.

[Summary] To explore the therapeutic effect of fecal microbiota transplantation (FMT) for severe psoriasis. A patient, male, 36 years old, diagnosed as severe plaque psoriasis for 10 years and irritable bowel syndrome (IBS) for 15 years, was administrated twice FMT via both upper endoscopy and colonoscopy with a 5‐week interval. The following items were used to evaluate responses: body surface area (BSA), psoriasis area and severity index (PASI), dermatology life quality index (DLQI), histological examination, intestinal symptoms, adverse reactions and serum level of tumor necrosis factor (TNF)‐α. After second FMT treatment for 5 weeks, aforementioned items were improved greatly compared with those before treatment. Moreover, IBS was completely relieved and no adverse reactions were observed during the treatment and follow‐up. In conclusion, FMT could be a novel therapy for psoriasis. Further clinical trials are needed to provide solid evidences.