草酸艾司西酞普兰与帕罗西汀治疗抑郁症的效果分析

Analysis of therapeutic effects of Escitalopram oxalate and Paroxetine on depression

目的:观察草酸艾司西酞普兰与帕罗西汀治疗抑郁症的临床效果。方法:选取84例抑郁症患者为研究对象,依据入院顺序将其分为观察组和对照组,每组42例。观察组予草酸艾司西酞普兰治疗,对照组予帕罗西汀治疗,比较两组临床疗效,抑郁症状评分及不良反应发生率。结果:观察组治疗总有效率为95.20%,高于对照组的78.60%,差异有统计学意义(P<0.05);治疗后,两组HAMD评分均较治疗前降低,且观察组HAMD评分低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为7.10%,低于对照组的23.80%,差异有统计学意义(P<0.05)。结论:草酸艾司西酞普兰治疗抑郁症较帕罗西汀疗效更佳,可尽快缓解患者抑郁症状,且安全性较高,值得推荐。

Objective: To study clinical effects of Escitalopram oxalate and Paroxetine on depression. Methods: 84 patients with depression admitted to our hospital were enrolled in the study. They were divided into observation group and control group according to the order of admission, 42 cases in each group. The observation group was treated with Escitalopram oxalate, while the control group was treated with Paroxetine. The clinical efficacy, depressive symptom score and adverse reaction rate were compared between the two groups. Results: The total effective rate of the observation group was 95.20%, which was higher than that of the control group (78.60%), and the difference was statistically significant (P<0.05). After the treatment, the HAMD scores of the two groups were lower than before the treatment, the HAMD score of the observation group was lower than that of the control group, and the differences were statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 7.10%, which was lower than that in the control group (23.80%), and the difference was statistically significant (P<0.05). Conclusions: Escitalopram oxalate is more effective than Paroxetine in the treatment of depression. It can relieve the depression symptoms as soon as possible, and it is safe and is worthy of recommendation.