程序性死亡蛋白-1及配体在心肌炎发病中的作用

Roles of programmed cell death protein-1 and its ligand in pathogenesis of myocarditis

心肌炎是目前临床仍面临挑战的一类心血管疾病,发病机制复杂,临床预后差。程序性死亡蛋白-1(PD-1)是重要的免疫检查点,与程序性死亡配体-1(PD-L1)结合可负向调节机体免疫反应,在心肌炎的发生发展中起重要作用。本文从PD-1/PD-L1调控T淋巴细胞活化、抑制肌钙蛋白抗体和心肌炎症反应等方面综述了PD-1/PD-L1在心肌炎发生中的作用,以期为有效诊治心肌炎寻求新靶点。

Myocarditis is still facing challenges clinically because of its complex pathogenesis and poor prognosis. Evidence shows that programmed cell death protein-1 (PD-1) is an important immunological checkpoint,and its binding to programmed cell death ligand -1 (PD-L1) can negatively regulate the immune response of the body and play an important role in the occurrence and development of myocarditis. This article reviews the roles of PD-1/PD-L1 in the pathogenesis of myocarditis in aspects of their regulation of T lymphocyte activation and inhibition of troponin antibody and myocardial inflammation in order to find a new target for the effective diagnosis and treatment of myocarditis.