卡马西平对三叉神经痛的疗效研究

Therapeutic Effect of Carbamazepine on Trigeminal Neuralgia

目的研究卡马西平对三叉神经痛患者的治疗效果。方法方便选择2017年1月—2018年1月因三叉神经痛来该院进行治疗的92例患者作为研究对象,随机分为研究组46例、对照组46例,其中对照组组患者予苯妥英钠片,研究组患者予卡马西平片,比较两组患者研究前后的疼痛程度与睡眠质量及临床疗效。结果在研究开始前,研究组与对照组患平均疼痛评分比较差异无统计学意义(t=0.638,P=0.525),但研究结束后,两组三叉神经痛患者的评分均较研究开始前明显降低,且研究组降低程度较对照组更为显著,差异有统计学意义(t=2.450,P=0.014)。研究开始前,研究组与对照组患者PSQI评分均较高,差异无统计学意义(t=0.697,P=0.488)。在研究结束后,两组患者PSQI量表评分均有所降低,且研究组降低程度更为显著,差异有统计学意义(t=2.195,P=0.031);研究组患者治疗总有效率为91.3%,对照组患者治疗总有效率为73.9%,研究组治疗总有效率高于对照组,差异有统计学意义(χ^2=4.84,P=0.0278)。结论卡马西平可以缓解三叉神经痛患者的疼痛程度、加强患者睡眠质量,相对于苯妥英钠具有更好的临床疗效,值得在临床推广使用。

Objective To study the therapeutic effect of carbamazepine on patients with trigeminal neuralgia.Methods A total of 92 patients who underwent treatment for trigeminal neuralgia from January 2017 to January 2018 were convenient selected and enrolled in the study.They were randomly divided into a study group of 46 patients and a control group of 46 patients.The control group received phenytoin.The patients in the study group were given carbamazepine tablets.The pain level,sleep quality and clinical efficacy of the two groups were compared before and after the study.Results Before the study,there was no significant difference between the study group and the control group(t=0.638,P=0.525).However,after the study,the scores of the patients with trigeminal neuralgia were significantly higher than before the study.The decrease was more significant in the study group than in the control group,and the difference was statistically significant(t=2.450,P=0.014).Before the study,the PSQI scores of the study group and the control group were higher,and the difference was not significant(t=0.697,P=0.488).At the end of the study,the PSQI scores of both groups were reduced,and the degree of reduction was more significant in the study group.The difference was statistically significant(t=2.195,P=0.031).The total effective rate of treatment in the study group was 91.3%,the total effective rate of the control group was 73.9%.The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(χ^2=4.84,P=0.027 8).Conclusion Carbamazepine can alleviate the pain level of patients with trigeminal neuralgia and enhance the sleep quality of patients.It has better clinical efficacy than phenytoin and is worthy of clinical use.