探讨美洛昔康联合阿仑膦酸钠治疗膝骨性关节炎合并骨质疏松的临床效果

Investigation on the Clinical Effect of Meloxicam Combined with Alendronate in the Treatment of Knee Osteoarthritis Complicated with Osteoporosis

目的观察、分析美洛昔康联合阿仑膦酸钠给药治疗膝骨性关节炎合并骨质疏松的临床效果,为该疾病的临床治疗提供有效方案。方法从该院自2015年3月—2018年3月接收并进行临床治疗的膝骨性关节炎合并骨质疏松患者资料中方便选取128例进行研究,根据患者质量方法的不同,将其分为两组,对照组64例患者接受美洛昔康给药治疗,观察组64例患者则进行美洛昔康与阿仑膦酸钠的联合给药治疗,以3个月为1个治疗周期,分别对比两组患者的临床治疗有效率、患处僵硬程度及疼痛程度、日常生活难度与生存质量情况。结果两组患者接受相同时间的差异性临床治疗后,观察组患者临床治疗有效率为93.8%,对照组患者临床治疗有效率为79.7%,两组指标差异有统计学意义(χ^2=5.43,P<0.05)。两组患者疼痛程度以及肢体僵硬程度均较治疗前降低,相比于对照组,观察组相关指标变化幅度更大,数据差异有统计学意义(P<0.05)。观察组患者日常生活难度明显降低,生存质量提高,两项指标均优于对照组,差异有统计学意义(P<0.05)。结论针对膝骨性关节炎合并骨质疏松患者实施美洛昔康与阿仑膦酸钠的联合给药治疗较美洛昔康单一性给药治疗具有更加显著的效果,能够进一步改善患者患处肢体僵硬情况,降低疼痛程度,提高患者生命质量,综合治疗有效率水平较高,值得进行临床应用与大范围推广。

Objective To observe and analyze the clinical effects of meloxicam combined with alendronate in the treatment of knee osteoarthritis complicated with osteoporosis,and provide an effective treatment for the clinical treatment of this disease.Methods From the hospital,from March 2015 to March 2018,Convenient selected 128 patients with osteoarthritis and osteoporosis were selected for clinical treatment.According to the patient's quality method,they were divided.For the two groups,64 patients in the control group received meloxicam,and 64 patients in the observation group received meloxicam combined with alendronate for 3 months as a treatment cycle.The clinical treatment efficiency,the degree of stiffness and pain of the affected area,daily life difficulty and quality of life were compared between the two groups.Results After the same period of differential clinical treatment,the effective rate of clinical treatment was 93.8%in the observation group and 79.7%in the control group.The difference between the two groups was obvious.the difference was statistically significant(χ^2=5.43,P<0.05).The pain degree and limb stiffness of the two groups were lower than those before treatment.Compared with the control group,the correlation index of the observation group was larger,and the difference was statistically significant(P<0.05).The daily life difficulty of the observation group was significantly reduced,and the quality of life was improved.Both indexes were superior to the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of meloxicam and alendronate in patients with knee osteoarthritis and osteoporosis has a more significant effect than meloxicam monotherapy,which can further improve the patient's affected area limb stiffness,lowering the degree of pain,improving the quality of life of patients,and the level of comprehensive treatment efficiency is high,which is worthy of clinical application and wide-ranging promotion.