卡培他滨化疗方案在复发转移性乳腺癌患者治疗前后CEA、CA199水平与化疗疗效及预后的关系

The relationship between CEA,CA199 levels and the efficacy and prognosis of chemotherapy regimen of capecitabine in patients with recurrent and metastatic breast cancer

目的采取卡培他滨化疗方案对复发转移性乳腺癌患者进行治疗,检测治疗前后癌胚抗原(CEA)、糖类抗原199(CA199)水平,分析其与近期疗效和远期预后的关系。方法选取该院2012年1月至2015年12月收治的45例行卡培他滨化疗方案治疗的复发转移性乳腺癌患者作为研究对象,以自动化学发光免疫分析仪采用化学发光法检测患者化疗前后CEA、CA199水平,分析2项指标与无进展生存期和总生存期的关系。结果化疗前,CEA、CA199基线水平正常和升高患者在平均无进展生存期和平均总生存期方面比较,差异均无统计学意义(P>0.05)。化疗后与化疗前基线水平比较,CEA、CA199水平下降幅度≥25%的患者平均无进展生存期和平均总生存期均长于下降幅度<25%的患者,差异均有统计学意义(P<0.05)。结论卡培他滨化疗方案治疗复发转移性乳腺癌对CEA、CA199水平有较大影响,从而影响患者近期疗效和远期预后,化疗前后对患者CEA、CA199水平进行检测,分析其变化情况,对化疗疗效及预后有较高预测价值。

Objective To test the levels of carcinoembryonic antigen(CEA),carbohydrate chain antigen 199(CA199)and so as to analyze the relationship of the two indicators with the efficacy and prognosis of chemotherapy regimen of capecitabine in patients with recurrent and metastatic breast cancer before and after treatment.Methods A total of 45 patients with recurrent and metastatic breast cancer treated with capecitabine chemotherapy regimen in our hospital from January 2012 to December 2015 were selected as the research objects.The levels of CEA and CA199 were detected by chemiluminescence immunoassay before and after chemotherapy,and the relationship between the two indexes and progression-free survival and overall survival was analyzed.Results Before chemotherapy,there was no significant difference in mean progression-free survival and mean total survival between patients with normal baseline CEA and CA199 and those with elevated baseline level(P>0.05).Compared with the baseline level before chemotherapy,the average progression-free survival and total survival of patients with CEA and CA199 decreased by 25%,or above than 25%after chemotherapy were longer than those of patients with less than 25%after chemotherapy,and the difference was statistically significant(P<0.05).Conclusion Capecitabine chemotherapy regimen in the treatment of recurrent and metastatic breast cancer have a greater impact on CEA and CA199 levels,thus affecting the short-term efficacy and long-term prognosis of patients.The detection of CEA and CA199 before and after chemotherapy should be strengthened,and the change of CA199 should be analyzed,which has a high predictive value for the efficacy and prognosis of chemotherapy.