呼吸道感染患儿肺炎衣原体IgM抗体结果分析

Analysis of the results of IgM antibody of Chlamydia pneumoniae in children with respiratory tract infection

目的通过检测及分析呼吸道感染患儿血清中肺炎衣原体IgM抗体,探讨患儿肺炎衣原体感染的流行病学特征。方法采用ELISA原理定性检测呼吸道感染患儿血清中肺炎衣原体IgM抗体,采用χ^2检验对不同性别、年份、季节及年龄数据进行分析。结果共检测8 657例呼吸道感染患儿标本,肺炎衣原体总阳性484例,总阳性率为5.59%,其中男、女患儿肺炎衣原体阳性率分别为5.12%、6.28%,女性患儿肺炎衣原体阳性率高于男性,差异有统计学意义(P<0.05)。2011-2017年肺炎衣原体阳性率分别为4.71%、8.88%、13.96%、4.95%、4.21%、1.06%、1.74%,2011-2013年肺炎衣原体阳性率逐年升高,2013-2017年肺炎衣原体阳性率有逐年降低趋势。春夏秋冬季肺炎衣原体阳性率分别为3.29%、5.86%、7.14%、6.35%,秋冬季肺炎衣原体阳性率较高,春季与其他季节肺炎衣原体阳性率比较,差异均有统计学意义(P<0.05)。0~1岁、>1~3岁、>3~6岁及>6~14岁患儿肺炎衣原体阳性率分别为2.86%、5.88%、7.28%、6.54%,0~1岁患儿肺炎衣原体阳性率最低,>3~6岁患儿肺炎衣原体阳性率最高,0~1岁患儿与其余年龄患儿肺炎衣原体阳性率比较,差异均有统计学意义(P<0.05),>1~3岁与>3~6岁患儿肺炎衣原体阳性率比较,差异有统计学意义(P<0.05)。结论女性肺炎衣原体阳性率高于男性,秋冬季肺炎衣原体阳性率较高,>3~6岁患儿肺炎衣原体阳性率最高。

Objective To investigate the epidemiological characteristics of Chlamydia pneumoniae infection in children with respiratory tract infection by detecting and analyzing the serum IgM antibody of Chlamydia pneumoniae.Methods The ELISA principle was used to determine the IgM antibody of Chlamydia pneumoniae in the serum of children,and the data of different sex,season and age were analyzed by 2 test.Results A total of 8 657 children with respiratory tract infection were detected.The number of positive cases was 484,the total positive rate was 5.59%.The positive rates of male and female children were 5.12%and 6.28%,respectively and the difference was statistically significant(P<0.05).The positive rates were 4.71%,8.88%,13.96%,4.95%,4.21%,1.06%and 1.74%from 2011 to 2017 respectively.The positive rates from 2011-2013 increased year by year,while the rates from 2013-2017 had been declined.The positive rates of spring,summer,autumn and winter were 3.29%,5.86%,7.14%and 6.35%respectively.The positive rates of autumn and winter were relatively higher,and the rate of spring had statistical significance with the other seasons(P<0.05).Positive rates of children aged 0-1,>1-3,>3-6 and>6-14 were 2.86%,5.88%,7.28%and 6.54%respectively.The rate of children aged 0-1 was the lowest,which of children aged>3-6 was the highest,differences of rate in children aged 0-1 had statistical significance with the other aged children(P<0.05).Conclusion The incidence of Chlamydia pneumoniae infection in female children is higher than that in male children,and rates of Chlamydia pneumoniae infection in autumn and winter are higher,as well as in children aged>3-6.