高血压肾病发生危险因素及防治对策

Risk factors and preventive measures for hypertensive nephropathy

目的探究引发高血压肾病的危险因素与防治应对措施。方法回顾性分析162例原发性高血压患者临床资料,并发慢性肾病(CKD)者纳入观察组(n=36),其他纳入对照组(n=126)。比较两组临床资料、高血压病情及合并症情况等各项因素,对单因素比较存在统计学意义者采取Logistic多元逐步回归分析。结果两组性别及合并高脂血症情况比较差异均无统计学意义,而年龄≥65岁、收缩压(SBP)≥180mmHg、合并有糖尿病及合并有高尿酸血症均是导致高血压肾病发生的独立危险因素(P<0.05)。结论高血压肾病发生与年龄、高血压严重程度及糖尿病、高尿酸血症等合并症情况密切相关,临床防治工作需紧密围绕上述因素展开,以期改善患者预后。

Objective To explore the risk factors and preventive measures for hypertensive nephropathy. Methods The clinical data of 162 patients with essential hypertension were retrospectively analyzed. Patients who were complicated with chronic kidney disease (CKD) were included in observation group (n=36), others were included in control group (n=126). The baseline data, hypertension conditions, and comorbidities were compared between the two groups. Logistic multiple stepwise regression analysis was performed for those with statistical significance in univariate comparisons. Results There was no significant difference in gender and combined hyperlipidemia between the two groups, and age ≥65 years old, systolic blood pressure (SBP)≥180 mmHg, combined diabetes and combined hyperuricemia were independent risk factors for occurrence of hypertensive nephropathy (P<0.05). Conclusion The occurrence of hypertensive nephropathy is closely related to the age, severity of hypertension and comorbidities of diabetes and hyperuricemia. The clinical prevention and treatment work should be closely carried out around the above factors in order to improve the prognosis of patients.