阿司匹林联合阿托伐他汀治疗糖尿病并发急性脑梗死的疗效与安全性分析

Efficacy and safety of aspirin combined with atorvastatin in the treatment of diabetes mellitus complicated with acute cerebral infarction

目的探讨阿司匹林联合阿托伐他汀治疗糖尿病并发急性脑梗死患者的临床疗效与安全性。方法选取2016年7月至2018年7月收治的糖尿病并发急性脑梗死患者92例,随机分为对照组与观察组,各46例。患者均给予降糖、降压等对症治疗,对照组采用阿司匹林治疗,观察组采用阿司匹林联合阿托伐他汀治疗,评价两组疗效、不良反应、血脂及神经功能缺损改善情况,并经超声检测评价恢复效果。结果观察组治疗有效率为95.65%,对照组为80.43%,比较差异具有统计学意义(P<0.05);观察组不良反应率为6.52%,对照组为10.87%,比较差异无统计学意义;治疗后,观察组血脂各指标TC、TG、LDL-C、HDL-C均明显改善,且与对照组比较差异具有统计学意义(P<0.05);治疗后,观察组斑块体积、收缩期峰值速度及hs-CRP明显改善,且改善程度显著优于对照组(P<0.05)。结论针对糖尿病并发急性脑梗死患者采用阿司匹林联合阿托伐他汀治疗对改善血脂及神经功能缺损效果显著,且可进一步稳定斑块,利于提高治疗效果,且不会明显增加不良反应,属于安全可靠的治疗方案。

Objective To investigate the clinical efficacy and safety of aspirin combined with atorvastatin in the treatment of diabetes mellitus complicated with acute cerebral infarction. Methods From July 2016 to July 2018, 92 patients with diabetes complicated with acute cerebral infarction were selected and randomly divided into control group and observation group, with 46 cases in each group, each group was given symptomatic treatment such as hypoglycemia and hypotension. The control group was given additional aspirin treatment, while the observation group was given additional aspirin combined with atorvastatin treatment. The efficacy, adverse reactions, lipid and neurological deficits of the two groups were evaluated. The recovery effect was evaluated by ultrasonography. Results The effective rate of the observation group was 95.65% and that of the control group was 80.43%, the difference was significant (P<0.05).The adverse reaction rate of the observation group was 6.52% and that of the control group was 10.87%, there was no statistical significance. After treatment, the indexes of TC, TG, LDL-C and HDL-C in the observation group were significantly improved, and the comparative advantage of the control group was obvious (P<0.05). After treatment, the plaque volume, systolic peak speed and hs-crp in the observation group were significantly improved, and the improvement degree was significantly better than that in the control group (P<0.05). Conclusion Aspirin combined with atorvastatin is a safe and reliable treatment for acute cerebral infarction patients with diabetic complications, which can improve blood lipid and neurological deficits, further stabilize the plaque, improve the therapeutic effect, and not significantly increase adverse reactions.