米非司酮配伍米索前列醇在治疗稽留流产的应用分析

Application analysis of mifepristone combined with misoprostol in treatment of missed abortion

目的分析对稽留流产患者给予米非司酮、米索前列醇联合治疗的临床效果。方法对本院2017年7月至2018年7月收治的110例稽留流产患者进行观察,将采用己烯雌酚单独治疗的35例患者作为参照组,将采用米非司酮、米索前列醇联合治疗的75例患者作为实验组,观察对比两组治疗效果。结果实验组完全流产率(70.67%)高于参照组,且清宫率(29.33%)低于参照组(P<0.05);实验组宫缩幅度大于参照组且手术时间、术中出血量、阴道流血时间均低于参照组(P<0.05)。结论米非司酮配伍米索前列醇具有促进宫缩、软化、扩张宫颈的作用,能提高妊娠物自然娩出率及完全流产率,出血量少,能降低患者清宫率及二次清宫率,减少相关并发症的发生。

Objective To analyze the clinical effect of Mifepristone and Misoprostol in the treatment of missed abortion. Methods 110 cases of missed abortion in our hospital from July 2017 to July 2018 were observed. 35 cases treated with diethylstilbestrol alone were taken as the reference group. 75 cases treated with mifepristone and misoprostol were taken as the experimental group. The therapeutic effects of the two groups were observed and compared. Results The complete abortion rate (70.67%) in the experimental group was higher than that in the reference group and the uterine clearance rate (29.33%) was lower than that in the control group (P<0.05);the uterine contraction amplitude in the experimental group was larger than that in the reference group and the operation time, intraoperative bleeding volume and vaginal bleeding time were lower than those in the reference group (P<0.05). Conclusion Mifepristone combined with misoprostol can promote uterine contraction, soften and dilate the cervix. It can improve the natural delivery rate and complete abortion rate of pregnancy, reduce bleeding, reduce the rate of uterine clearance and secondary uterine clearance, and reduce the incidence of related complications.