石墨烯量子点的光热和光动力效应在杀菌中的应用

Applications of combined photothermal and photodynamic effects of graphene quantum dots in antibacterium

石墨烯及其衍生物作为一类较好的抗菌性材料,在相关领域内受到关注.而石墨烯量子点(graphene quantum dots,GQDs)作为石墨烯家族的重要一员,目前在生物医学领域中的应用侧重于药物输送、肿瘤治疗和生物检测.以石墨粉为原料合成了GQDs,在655nm激光诱导下,该GQDs迅速将光能转换为热能,同时产生活性氧.可以发现,0.6mg/mL的GQDs在低功率密度的655nm激光照射15min的情况下,可将大肠杆菌完全杀灭,而单独激光照射和单独GQDs处理不影响细菌活性.GQDs因具有较大的比表面积而可以装载可观的抗菌药物,且其生物相容性、溶解性和稳定性都十分优秀,是一种未来有潜力的抗菌材料.

As a class of excellent antibacterial materials, graphene and its derivatives have attracted much research attention. As an important member of the graphene family, however, graphene quantum dots (GQDs) is mainly focused on drug delivery, cancer treatment and biological testing. In this study, GQDs was prepared to kill Escherichia coli (E. coli) under 655-nm laser irradiation. GQDs was synthesized from graphite powder. Under the laser irradiation, the as-synthesized GQDs rapidly converted the laser energy to heat and produced reactive oxygen species. Escherichia coli incubated with 0.6 mg/mL of GQDs was completely killed after 15 min of irradiation, while the Escherichia coli growth was not affected by GQDs or laser alone. With huge surface area used for loading considerable drugs, excellent biocompatibility, solubility and stability, GQDs may be a potential antibacterial material.