中西医结合治疗对神经胶质瘤患者血清p53、VGEF表达的影响

Effect of Integrated Chinese-Western Therapy on Serum p53,VGEF Expression in Patients with Glioma

目的观察姜黄消瘤汤联合化疗对神经胶质瘤患者术后的临床疗效。方法 60例神经胶质瘤患者随机分为治疗组和对照组各30例。对照组术后给予化疗干预,治疗组在对照组的基础上给予姜黄消瘤汤联合治疗,均以28d为1个疗程,连续治疗4个疗程。观察两组治疗前后近期临床疗效、血清肿瘤抑制蛋白 53(p53)、血管内皮生长因子(VGEF)水平、中医证候积分、毒副反应情况。结果治疗组近期临床疗效和疾病控制方面优于对照组(P<0.05);治疗后两组中医证候积分、血清 p53、VGEF 水平较治疗前下降(P<0.05),治疗组降低程度高于对照组(P<0.05);治疗组发生胃肠道反应、骨髓抑制、深静脉血栓形成的病例均少于对照组(P<0.05)。结论姜黄消瘤汤联合化疗对神经胶质瘤患者术后疗效明确,改善中医症状,下调血清p53、VGEF水平,并具有增效减毒作用。

Objective To observe the clinical curative effect of Jianghuang Xiaoliu decoction on postoperative malignant glioma. Methods 60 cases of patients with glioma were randomly divided into treatment group and control group,30 cases in each group. Control group received chemotherapy intervention after surgery while observation group was treated with Jianghuang Xiaoliu decoction on the basis of control group. Both groups were treated with 28d as a cycle,continuously treated for 4 cycles. The short-term clinical efficacy,TCM symptom score,tumor suppressor protein 53(p53),vascular endothelial growth factor (VGEF)level and adverse reaction were observed before and after treatment. Results Short-term clinical efficacy and disease control of treatment group were better than those of control group (P<0.05);after treatment,the TCM symptom scores,serum p53 and VGEF levels in both groups were lower than those before treatmen(t P<0.05),the degree of reduction in treatment group was higher than that in control group(P<0.05);the adverse reaction in treatment group was less than that in control group(P<0.05).