广州市79例输入性疟疾患者临床资料回顾性分析

Retrospective analysis of clinical data of 79 cases with imported malaria in Guangzhou

目的分析输入性疟疾患者临床资料,为临床早期诊断、治疗以及预后判断提供参考数据。方法回顾性分析广州地区79例输入性疟疾患者的流行病学资料及实验室血常规、生化等检测指标结果,并与80例健康体检人员的实验室指标进行比较,采用多因素二元Logistic对输入性疟疾患者的实验室指标作逐步回归分析,并将79例疟疾患者治疗前后的实验室指标进行比较。结果与健康组比较,病例组的WBC、RBC、HGB、PLT均下降,而ALT、AST和TBIL的水平则升高,差异具有统计学意义(P<0.05);当怀疑疟疾感染时,AST和TBIL水平越高,HGB和PLT水平越低,患疟疾的可能性越大;与治疗前对比,疟疾组患者治疗后的WBC、PLT的水平升高,RBC、HGB、AST、TBIL、CRP、PCT水平均降低(P<0.05),而两组ALT的水平均无统计学差异(P>0.05)。结论患者血液血常规、生化指标检测有助于临床对疟疾感染的及早诊治和预后判断。

Objective To retrospectively analyze the clinical data with imported malaria,and to provide fundamental statistics for early clinical diagnosis,treatment and prognosis.Methods The epidemiological data and the results of laboratory tests of 79 cases with imported malaria in Guangzhou were retrospective analyzed,which were compared with the laboratory results of 80 healthy physical examinations.Multi-factor binary logistic Stepwise regression analysis was performed on laboratory indicators of patients with imported malaria.Laboratory test indicators were compared between different species malaria cases.The laboratory parameters of malaria patients before and after treatment were compared in 79 cases.Results Compared with the healthy group,the levels of WBC,RBC,HGB,and PLT of the malaria group decreased,while the levels of ALT,AST,and TBIL increased(P<0.05).When malaria infection was suspected,the higher the level of AST and TBIL,the lower the level of HGB and PLT,the greater the possibility of malaria.The levels of WBC and PLT increased after treatment,while the levels of RBC,HGB,AST,TBIL,CRP,PCT decreased respectively(P<0.05),but there was no difference in the levels of ALT between these two groups(P>0.05).Conclusion Laboratory indicators in patients contribute to clinical early diagnosis and prognosis of malaria infections.