四联根除幽门螺杆菌新方案的探讨

Discussion on a new scheme of quadruple eradication of Helicobacter pylori

目的观察比较相同疗程的两组经典药物不同组合方式对幽门螺杆菌(H.pylori)的根除效果。方法82例H.pylori阳性患者,采用随机数字表法分为试验组(33例)与对照组(49例)。试验组给予雷贝拉唑、胶体果胶铋、四环素、呋喃唑酮治疗;对照组给予雷贝拉唑、胶体果胶铋、阿莫西林、克拉霉素治疗。比较两组患者H.pylori根除率及不良反应发生率。结果对照组H.pylori根除率为91.84%,试验组H.pylori根除率为96.97%,两组比较,差异无统计学意义(P>0.05)。两组患者治疗期间均无不良反应发生。结论雷贝拉唑、胶体果胶铋、四环素、呋喃唑酮组合较雷贝拉唑、胶体果胶铋、阿莫西林、克拉霉素组合H.pylori根除率高,无不良反应发生,可作为根除H.pylori的临床优选治疗方案。

Objective To observe and compare the eradication effect of different combinations of two classical drugs on Helicobacter pylori(H.pylori)in the same course of treatment.Methods A total of 82 H.pylori positive patients were divided into experimental group(33 cases)and control group(49 cases)by random number table method.The experimental group was treated by rabeprazole,colloidal bismuth pectin,tetracycline and furazolidone,and the control group was treated by rabeprazole,colloidal bismuth pectin,amoxicillin and clarithromycin.The H.pylori eradication rate and incidence of adverse reactions in the two groups was compared.Results The H.pylori eradication rate was 91.84%in the control group,which was 96.97%in the experimental group,and the difference was not statistically significant(P>0.05).There were no adverse reactions during treatment in both groups.Conclusion Compared with rabeprazole,colloidal bismuth pectin,amoxicillin and clarithromycin,the eradication rate of rabeprazole,colloidal bismuth pectin,tetracycline and furazolidone combination is higher,and there are no adverse reactions in two regimens.It could be used as a clinical optimal treatment for the eradication of H.pylori.