肺炎支原体血清学标志物研究进展

Progress of serological detection markers of mycoplasma pneumonia

肺炎支原体是常见呼吸道感染病原微生物之一,具有独特的流行病学特点.除引起呼吸道症状外,肺炎支原体感染还会引起其他如消化、神经和泌尿系统等损伤.患者感染肺炎支原体后症状体征的特异性较差造成临床诊断困难.肺炎支原体感染后首选药物为大环内酯类,但近年来耐大环内酯类肺炎支原体检出率升高给临床诊治带来新的挑战.肺炎支原体主要检出手段包括分离培养、聚合酶链式反应(PCR)检测和血清学诊断.较分离培养、PCR等检测手段,血清学检测具有耗时短、经济和可行性强等特点.不同血清学标志物敏感性及特异性存在差异.本文就肺炎支原体血清学标志物的研究进展进行综述.

Mycoplasma pneumonia, one kind of common pathogenic microorganisms which could lead to respiratory infection, has unique epidemiologic characteristics. Beside the respiratory symptoms, mycoplasma pneumonia infection could also cause other damages including digestive, nervous, urinary system and so on. It is difficult to make clinical diagnosis because the symptoms and signs of patients infected by mycoplasma pneumonia are not specific. Once infected by mycoplasma pneumonia, macrolides antibiotics are preferred drugs. In recent years, higher detection rate of macrolides-resistence mycoplasma pneumonia put forward new challenge for clinical diagnosis and treatment. The main detection methods include separation culture, Polymerase chain reaction (PCR) detection and serological diagnosis. Compared with separate culture, PCR detection and other detection methods, serological detection is time-saving, more economic, and has strong feasibility and so on. There are differences between different serological markers in sensitivity and specificity. In this paper, the research progress on the serologic markers of mycoplasma pneumonia was reviewed.