妊娠前半期甲状腺功能异常与妊娠期糖尿病的临床观察

Relationship Between Pregnancy Thyroid Dysfunction and Gestational Diabetes

目的探究妊娠前半期甲状腺功能异常与妊娠期糖尿病的关系。方法选择2016年12月-2018年6月作为研究时段,取150例妊娠12周的孕妇作为研究对象,所有研究对象均实施妊娠前半期甲状腺功能检测,以功能检测异常与非异常为分组原则,将150例患者分为对照组(77例)、试验组(73例),对照组为妊娠前半期甲状腺功能正常者;试验组为妊娠前半期甲状腺功能异常者。对比2组甲状腺功能异常率,同时采用Spearman分析血糖水平与TSH、FT4相关性。结果与对照组比较妊娠期糖尿病发病率,试验组明显高于对照组(P<0.05);经Spearman分析,FT4水平与空腹血糖呈负相关(r=-0.745),与餐后1小时、2小时血糖水平无相关性;TSH与空腹血糖、餐后1小时、2小时血糖水平无相关性。结论妊娠前半期甲状腺功能异常会引发妊娠期糖尿病,故在产检中,应重视于妊娠前半期甲状腺功能的检查,尽早发现病情,给予相应的处理措施,以提高母婴安全。

Objective To explore the relationship between thyroid dysfunction and gestational diabetes in the first half of pregnancy. Methods From December 2016 to June 2018, as the study period, 150 pregnant women with a 12-week pregnancy were enrolled as the study subjects. All subjects underwent thyroid function tests in the first half of pregnancy, with functional detection abnormalities and non-abnormalities as grouping principles. 150 patients were divided into control group (77 cases) and experimental group (73 cases). The control group was normal thyroid function in the first half of pregnancy;the experimental group was thyroid dysfunction in the first half of pregnancy. The rate of thyroid dysfunction in two groups was compared, Simultaneous analysis of blood glucose levels and TSH, FT4 correlation used Spearman. Results Compared with the control group, the incidence of gestational diabetes mellitus in the experimental group was significantly higher than that in the control group (P < 0.05). Spearman analysis showed that FT4 level was negatively correlated with fasting blood glucose (r =-0.745), but not with postprandial blood glucose levels of 1 hour and 2 hours;TSH had no correlation with fasting blood glucose, postprandial blood glucose levels of 1 hour and 2 hours. Conclusion Thyroid dysfunction in the first half of pregnancy can cause gestational diabetes. Therefore, in the postpartum examination, attention should be paid to the examination of thyroid function in the first half of pregnancy. The condition should be detected as soon as possible, and corresponding treatment measures should be given to improve the safety of mother and infant.