运动康复对慢性心力衰竭患者血清NT-proBNP、hscTnT水平及心功能的影响

Influence of exercise rehabilitation on serum NT-proBNP,hscTnT levels and cardiac function in patients with chronic heart failure

目的:研究运动康复对慢性心力衰竭患者血清N末端脑钠肽前体(NT-proBNP)、高敏心肌肌钙蛋白T(hscTnT)水平及心功能指标影响。方法:我院的慢性心力衰竭患者140例被随机分为常规组(采用常规治疗)与运动康复组(在接受常规治疗的基础上进行运动康复),每组70例,治疗3周后,比较两组患者康复干预前后血清NT-proBNP、hscTnT水平及心功能指标变化。结果:治疗3周后,与常规组比较,运动康复组患者血清NT-proBNP[(2.60±0.53)μg/L比(2.11±0.52)μg/L]、hscTnT[(0.38±0.12)μg/L比(0.30±0.09)μg/L]水平显著降低,LVEF[(43.10±6.21)%比(52.13±5.10)%]、左室舒张早期峰值流速与晚期峰值流速比值(E/A)[(0.94±0.44)比(1.40±0.56)]显著提高,左室舒张末期内径(LVEDd)[(56.78±6.21)mm比(50.10±4.21)mm]、左室收缩末期内径(LVESd)[(48.11±5.88)mm比(35.00±6.20)mm]、左心房内径(LAD)[(44.01±5.69)mm比(34.26±6.09)mm]、左室心肌重量指数(LVMI)[(185.01±31.34)g/m2比(125.89±43.52)g/m^2]均显著下降(P均=0.001)。结论:慢性心衰患者采用运动康复治疗能够显著降低血清NT-proBNP、hscTnT水平,改善心功能。

Objective: To study influence of exercise rehabilitation on serum levels of N terminal pro brain natriuretic peptide (NT-proBNP) and high sensitive cardiac troponin T (hscTnT) and cardiac function indexes in patients with chronic heart failure (CHF). Methods: A total of 140 CHF patients treated in our hospital were randomly and equally divided into routine group (received routine treatment) and exercise rehabilitation group (received exercise rehabilitation based on routine group), both groups were treated for three weeks. Serum levels of NT-proBNP, hscTnT and cardiac function indexes were measured and compared between two groups before and after rehabilitative intervention. Results: Compared with routine group after three-week treatment, there were significant reductions in serum levels of NT-proBNP [(2.60±0.53)μg/L vs.(2.11±0.52)μg/L], hscTnT[(0.38±0.12)μg/L vs.(0.30±0.09)μg/L], left ventricular end-diastolic dimension (LVEDd)[(56.78±6.21)mm vs.(50.10±4.21)mm], left ventricular end-systolic dimension (LVESd)[(48.11±5.88)mm vs.(35.00±6.20)mm], left atrial diameter (LAD)[(44.01± 5.69)mm vs.(34.26±6.09)mm] and left ventricular mass index (LVMI)[(185.01±31.34) g/m 2 vs.(125.89±43.52) g/m^2 ], and significant rise in LVEF [(43.10±6.21)% vs.(52.13±5.10)%] and left ventricular early/late diastolic peak flow velocity (E/A)[(0.94±0.44) vs.(1.40±0.56)] in exercise rehabilitation group, P =0.001 all. Conclusion: Exercise rehabilitation can significantly reduce serum NT-proBNP and hscTnT levels, improve cardiac function in CHF patients.