酒石酸美托洛尔治疗UAP的疗效及对血脂、炎性因子水平的影响

Therapeutic effect of metoprolol tartrate on UAP and its influence on levels of blood lipids and inflammatory factors

目的:观察酒石酸美托洛尔治疗不稳定型心绞痛(UAP)的临床疗效及对患者血脂、炎性因子水平的影响。方法:本院2016年1月~2017年6月收治的96例UAP患者被随机均分为常规治疗组及美托洛尔组(在常规治疗基础上加用酒石酸美托洛尔),两组均连续治疗14d。观察比较两组治疗前后心绞痛发作疼痛程度VAS评分、hsCRP、肿瘤坏死因子(TNF)-α、基质金属蛋白酶(MMP)-9、血浆脑钠肽(BNP)水平,以及临床疗效。结果:与常规治疗组比较,治疗后美托洛尔组心绞痛发作次数[(5.67±3.57)次/周比(2.81±1.18)次/周]、发作持续时间[(4.51±1.43)min/次比(1.37±0.87)min/次]、疼痛程度VAS评分[(5.69±0.87)分比(4.08±0.61)分]、血清hsCRP[(18.34±4.16)mg/L比(14.59±3.98)mg/L]、TNF-α[(173.41±21.42)μg/L比(119.03±21.83)μg/L]、MMP-9[(368.51±38.24)μg/L比(303.77±29.97)μg/L]、血浆BNP[(869.78±82.89)pg/ml比(721.36±75.62)pg/ml]水平降低更显著,P均=0.001。结论:酒石酸美托洛尔可提高对UAP疗效,显著改善心绞痛、降低血清炎性因子水平。

Objective: To observe therapeutic effect of metoprolol tartrate on unstable angina pectoris (UAP) and its influence on levels of blood lipids and inflammatory factors. Methods: A total of 96 UAP patients treated in our hospital from Jan 2016 to Jun 2017 were randomly and equally divided into routine treatment group and metoprolol group (received metoprolol tartrate based on routine treatment), both groups were continuously treated for 14d. Onset times and duration of angina pectoris, visual analogue scale (VAS) score for pain degree, levels of blood lipids, serum hsCRP, TNF-α, MMP-9 and plasma BNP, and therapeutic effect were observed and compared between two groups before and after treatment. Results: Compared with routine treatment group after treatment, there were significant reductions in onset times [(5.67±3.57) times/week vs.(2.81±1.18) times/week] and duration [(4.51±1.43)min/time vs.(1.37±0.87) min/time] of angina pectoris, VAS score for pain degree [(5.69±0.87) scores vs.(4.08±0.61) scores], levels of serum hsCRP [(18.34±4.16)mg/L vs.(14.59±3.98)mg/L], TNF-α[(173.41± 21.42)μg/L vs.(119.03±21.83)μg/L], MMP-9[(368.51±38.24)μg/L vs.(303.77±29.97)μg/L] and plasma BNP [(869.78±82.89)pg/ml vs.(721.36±75.62)pg/ml] in metoprolol group, P =0.001 all. Conclusion: Metoprolol tartrate can improve therapeutic effect, significantly improve angina and reduce serum levels of inflammatory factors in UAP patients.