血管内皮细胞钙稳态的调节机制

Regulation mechanism of calcium homeostasis in vascular endothelial cells

血管内皮细胞是血管的屏障,内皮损伤会导致多种疾病发生,其机制与细胞内钙信号失衡有关。Ca^2+是细胞内外信息传递的第二信使,其启动内皮细胞中的信号,对控制血管张力和内皮通透性有重要作用。近年来血管内皮细胞损伤机制的研究成为热点,钙稳态失衡是关键因素,具体机制仍不清楚。本文通过对血管内皮细胞质膜钙运转和胞内钙库调节失衡研究的综述,以期为与Ca^2+调控相关疾病的防治提供新的思路。

Vascular endothelial cells are the barrier of blood vessels. Endothelial injury will lead to occurrence of multiple diseases, whose mechanism is related to intracellular calcium signal pool regulation. Ca^2+ is a secondary messenger for information delivery inside and outside cells, it initiates endothelial cell signals and plays an important role in controlling vascular tension and endothelial permeability. Study on mechanism of vascular endothelial cell injury has become a hot topic in recent years, and calcium homeostasis imbalance is the key factor, whose mechanism is still not clear. The present article reviewed regulating mechanisms of vascular endothelial cytoplasmic membrane calcium transport and intracellular calcium pool regulation, aimed at providing new thinking for prevention and treatment of calcium regulation related diseases.