伯基特淋巴瘤发病机制的研究进展

Research advances in pathogenesis of Burkitt lymphoma

伯基特淋巴瘤(Burkitt lymphoma,BL)是一种高度侵袭性非霍奇金淋巴瘤,是增长最快的恶性肿瘤之一。BL病因和发病机制尚未完全阐明,既往研究表明BL可能与c-myc易位等有关。近些年对BL病因学的研究逐渐深入,在基因突变和表观调控领域发现了一些新的致瘤机制。本综述将从基因突变和表观调控角度阐述BL发病机制的研究进展。

Burkitt lymphoma (BL) is a type of highly invasive non-Hodgkin’s lymphoma and one of the most rapidly growing malignant tumors. The etiology and pathogenesis of BL have not been fully elucidated. Previous studies have shown that BL may be related to c-myc translocation. The etiology of BL has been thoroughly studied in recent years, and some new tumorigenic mechanisms have been found in the field of gene mutation and epigenetic regulation. The aim of this review is to elucidate the pathogenesis of BL from the perspective of gene mutation and epigenetic regulation.