持续性高+Gz加速度生理响应的动物实验研究进展

Progress in animal experimental research on the physiological response to persistent high +Gz acceleration

本文回顾了高+Gz暴露对动物心血管、呼吸、中枢神经、内分泌及其他组织器官的影响及生理机制,并讨论了上述研究成果和理论机制向人体推广的可行性。动物实验的结果表明,高+Gz对机体的整体和各器官局部血液循环都会产生显著影响,从而造成心血管、肺组织、内分泌腺体及脑组织等的超微结构损伤。随着放射免疫及生物化学法、力学有限元模型、基因芯片等方法和技术的应用,将大幅度提高对高+Gz载荷下的生理应激反应和致病机制的认知程度。

This study reviewed the effects and physiological response mechanisms of high +Gz exposure on the cardiovascular,respiratory,central nervous and endocrine systems and other tissues and organs,and to discuss if these results and theoretical mechanisms could be adapted to human body.The results showed that high +Gz has a significant impact on the blood circulation in the whole body and various organs,resulting in ultrastructural alterations of the cardiovascular system,lung tissue,endocrine glands and brain tissue,etc.With the application of radioimmunoassay and biochemical method,mechanical finite element model,gene chip and other technologies,better understanding of the physiological stress response and pathogenic mechanism under high +Gz load will be achieved.