近年来ɑ-羰基二硫缩烯酮类化合物的Vilsmeier反应

Vilsmeier Reaction of α-Carbamoyl Ketene-S,S-acetals in Recent Years

在有机合成中,Vilsmeier反应一直是广泛应用的一类有机反应,其中Vilsmeier试剂是取代酰胺和卤化物形成的混合物。在Vilsmeier试剂的作用下,反应物发生甲酰化、氯化甲酰化、芳香化、重排、脱水、环化等反应,制备了大量在农药、染料和医药方面具有重要应用价值的化合物。本文主要介绍了ɑ-羰基二硫缩烯酮的Vilsmeier反应。

The Vilsmeier reaction had historically been a topic of great interest to organic chemists, The Vilsmeier reaction provided a facile entry into large numbers of aromatic and het-eroaromatic systems. Acylation, chloroformylation, aromatization, rearrangement, dehydration and cyclization were the most reactions of Vilsmeier reagents. The application of Vilsmeier reagents in ɑ-oxoketenedithioaeetal in recent years was introduced.