新生血管成熟度:易损动脉粥样硬化斑块的干预靶点

Neovascular maturity:the intervention target of vulnerable atherosclerotic plaques

动脉粥样硬化斑块内不成熟的新生血管与斑块易损性密切相关。斑块内以炎症为核心的病理因素干扰新生血管内皮细胞间连接形成、壁细胞覆盖和基底膜沉积,阻碍新生血管成熟。改善新生血管成熟度是稳定易损动脉粥样硬化斑块的潜在干预靶点。

Immature neovascularization in atherosclerotic plaques is closely associated with plaque vulnerability.Pathological factors with inflammation as the core in the plaques interfere with the formation of junction between endothelial cells,parietal cell coverage and basement membrane deposition,hindering the maturation of neovascularization.Improving neovascular maturity is a potential intervention target for stabilizing vulnerable atherosclerotic plaques.