摘要
目的:研究快速降解的弹性体PGS/PCL人工血管在体内改建为功能性肌性颈动脉的可能性。方法:体外构建PGS/PCL双层人工血管,植入大鼠颈动脉,12个月后取材,对新生血管进行评估。结果:12个月后,PGS/PCL人工血管改建成了与自体颈动脉结构和组织学方面均相似的细胞化的新生血管。结论:PGS/PCL人工血管在体内可以改建成为肌性、功能性的动脉血管。
Objective: To investigate the feasibility of fast degrading and elastomeric PGS/PCL artificial vessel in the reconstruction of carotid artery. Methods:PGS/PCL artificial vessel was fabricated in vitro. Artificial vessels were interpositioned in rat carotid arteries, the results were evaluated at 1 year postoperatively. Results: PGS/PCL artificial vessel remodeled into cellular "neoarteries" approxi mate to native carotid arteries. Conclusion: PGS/PCL artificial vessel can be remodeled into muscular and functional artery in vivo.
作者
杨欣
杨帆
郭晓宝
吴炜
高瞻
YANG Xin;YANG Fan;GUO Xiaobao;WU Wei;GAO Zhan(Urumchi, Department of Oral and Maxillofacial Surgery, General Hospital of Xinjiang Military Region,830000 China;Regiment Medical Company, The People's Liberation Army 69330 Troop, Barkol;State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, the Fourth Military Medical University)
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2019年第5期647-652,共6页
Journal of Practical Stomatology
基金
国家自然科学基金(编号:31370997)
国家高技术研究发展计划(编号:863计划,2015AA020920)
关键词
颈动脉重建
颈动脉置换
聚癸二酸丙三酮酯(PGS)
Reconstruction of carotid artery
Carotid artery replacement
Poly(Glycerol Sebacate)(PGS)
