四联疗法联合铝碳酸镁治疗结直肠癌合并幽门螺旋杆菌感染患者的效果

Efficacy of Four Therapy Combined with Magnesium Aluminum Carbonate in the Treatment of Colorectal Cancer Patients with Helicobacter Pylori Infection

目的探究四联疗法联合铝碳酸镁治疗结直肠癌合并幽门螺旋杆菌(HP)感染患者的效果及对血清Ⅰ型前胶原氨端肽原、胃泌素17水平的影响。方法选择2016年1月—2018年1月收治的结直肠癌合并幽门螺旋杆菌感染的患者93例作为研究对象,按照治疗方法不同分为对照组41例和观察组52例。对照组使用四联疗法治疗,观察组在对照组基础上同时联合铝碳酸镁治疗。结果观察组治疗后4天、8天和14天的HP清除率均显著高于对照组(P<0.05)。治疗前对照组和观察组血清白细胞介素-6(IL-6)、C反应蛋白(CPR)水平比较,差异无统计学意义(P>0.05);治疗后观察组血清IL-6、CPR水平显著低于对照组,差异均有统计学意义(P<0.05),观察组下降幅度大于对照组(P<0.05)。结论铝碳酸镁联合四联疗法可有效提高HP清除率并降低血清炎性因子水平,降低血清G-17水平,提高预后,同时还可以提高PINP水平。

OBJECTIVE To explore the quadruple therapy in combination with hydrotalcite treatment of patients with colorectal cancer com plicated by helicobacter pylori(HP)infection and the effect of type of serum Ⅰ before collagen peptide the original ammonia,the influ ence of the stomach(17 level).METHODS From January 2016 to January 2018,93 patients with colorectal cancer and helicobacter pylo ri infection were selected as study subjects,and divided into 41 patients in the control group and 52 patients in the observation group ac cording to different treatment methods. The control group was treated with quadruple therapy,while the observation group was treated with magnesium aluminum carbonate on the basis of the control group.RESULTS The HP clearance rate of the observation group was sig nificantly higher than the control group at 4,8 and 14 days after treatment(P <0.05). There was no significant difference in serum inter leukin-6(il-6)and c-reactive protein(CPR)levels between the control group and the observation group before treatment(P>0.05). Af ter treatment,serum il-6 and CPR levels in the observation group were significantly lower than those in the control group,with statisti cally significant differences(P <0.05),and the decrease in the observation group was greater than that in the control group(P <0.05). CONCLUSION Magnesium aluminum carbonate combined with quadruple therapy could effectively improve HP clearance rate,reduce serum inflammatory factor level,reduce serum g-17 level and improve prognosis. It also improved PINP levels.