右美托咪定对全麻下老年骨科手术患者苏醒期躁动及认知功能的影响

Effect of Dexmedetomidine on Agitation and Cognitive Function in Elderly Patients Undergoing Orthopedic Surgery under General Anesthesia

目的探讨右美托咪定对全麻下老年骨科手术患者苏醒期躁动及认知功能的影响。方法按随机数字表法将于我院行全麻下老年骨科手术的患者80例分为两组,每组各40例,对照组在麻醉前给予0.9%氯化钠注射液,研究组麻醉前给予右美托咪定。比较两组术后苏醒时间、苏醒期躁动发生率及认知功能。结果研究组苏醒时间为(19.64±5.08)min,低于对照组的(34.79±5.86)min(P<0.05);研究组苏醒期躁动发生率明显低于对照组(P<0.05);研究组简易精神状态评价量表(MMSE)评分高于对照组(P<0.05);研究组术后7天认知功能障碍发生率明显低于对照组(P<0.05)。结论右美托咪定可缩短全麻下老年骨科手术患者术后苏醒时间,降低苏醒期躁动发生率,减轻认知功能受麻醉的影响。

OBJECTIVE To investigate the effects of dexmedetomidine on agitation and cognitive function in elderly patients undergoing or thopedic surgery under general anesthesia.METHODS According to the random number table method, 80 patients with general orthope dic surgery underwent general anesthesia in target hospital were divided into two groups, 40 cases each. The control group was given 0.9% sodium chloride injection before anesthesia, and the study group was given right before anesthesia. The postoperative recovery time, the incidence of agitation and cognitive function in the two groups were compared.RESULTS The recovery time of the study group was(19.64±5.08)min, which was lower than that of the control group(34.79±5.86)min(P <0.05). The incidence of agitation in the study group was significantly lower than that of the control group(P <0.05). The score of simple mental state evaluation scale(MMSE) was higher than that of the control group(P <0.05). The incidence of cognitive dysfunction was significantly lower in the study group than in the control group(P <0.05).CONCLUSION Dexmedetomidine could shorten the postoperative recovery time of elderly orthopedic sur gery patients under general anesthesia, reduce the incidence of agitation during recovery, and reduce the impact of cognitive function on anesthesia.