288例住院患者病毒性肝炎相关肝硬化现状及影响因素分析

Analysis on Current Status and Influencing Factors of Viral Hepatitis-related Liver Cirrhosis in 288 Inpatients

目的探讨病毒性肝炎相关肝硬化(liver cirrhosis,LC)现状及影响因素。方法选取288例病毒性肝炎患者作为研究对象,分为LC组(n=92)和无LC组(n=196)。评估LC组Child-Pugh分级,比较患者肝纤维化指标,比较有无LC组一般资料及病例资料,并行logistic回归分析。结果(1)各组PCⅢ、C-Ⅳ、LN和HA水平对比差异均有统计学意义(P<0.05);(2)LC组较无LC组≥60岁、饮酒史、合并糖尿病、合并高血压和认知程度差比例高(P<0.05),病毒性肝炎病程<1年、坚持抗病毒治疗和经常运动比例低(P<0.05);(3)影响LC发生的独立危险因素,如饮酒史、糖尿病和病毒性肝炎病程有差异(P<0.05),保护因素为运动习惯、坚持抗病毒治疗。结论病毒性肝炎患者发生LC的影响因素较多,应及早对高危患者采取预防措施。

OBJECTIVE To explore the current status and influencing factors of viral hepatitis-related liver cirrhosis(LC). METHODS 288 patients with viral hepatitis were selected for the study and were divided into LC group(n=92)and non-LC group(n=196). The Child- Pugh grading was evaluated in LC group,and the liver fibrosis indexes were compared. The general data and case data were compared be tween LC group and non-LC group,and Logistics regression analysis was used. RESULTS There were significant differences in the levels of PCIII,C-IV,LN and HA among groups(P <0.05). Compared with non-LC group,the proportions of patients with age≥60 years old,drinking history,diabetes mellitus,hypertension and poor disease cognition were higher in LC group(P <0.05)while the propor tions of patients with course of viral hepatitis <1 year,adherence to antiviral therapy and regular exercise were lower(P <0.05). The in dependent risk factors for LC occurrence were drinking history,diabetes mellitus and course of viral hepatitis(P <0.05),and protective factors were exercise habits and adherence to antiviral therapy. CONCLUSION There were many influencing factors for LC occurrence in patients with viral hepatitis. Preventive measures should be taken early on high-risk patients.