CD133与CD44蛋白在肝细胞癌组织中的表达及临床意义

Expression of CD133 and CD44 proteins in hepatocellular carcinoma tissue and its clinical significance

目的:观察CD133和CD44蛋白在肝细胞癌(hepatocellularcarcinoma,HCC)组织中的表达,探讨其与临床病理特征及预后的关系。方法:收集43例手术切除的HCC病理标本,采用免疫组化S-P法检测CD133及CD44蛋白的表达情况,分析其与临床特征及预后的关系。结果:在HCC组织中CD133的阳性率为58.1%(25/43),CD44的阳性率为69.8%(30/43),两者均高于其在癌旁组织中的表达(P<0.05)。CD133与肿瘤直径、分化程度、门静脉癌栓及临床分析密切相关,CD44与门脉癌栓及临床分期有关。两者的阳性表达均可降低患者3年生存率。结论:HCC组织中CD133和CD44蛋白的表达高于癌旁组织,其表达与HCC的进展及预后相关。

Objective: To observe the expression of CD133 and CD44 proteins in hepatocellular carcinoma(HCC) tissue, and to explore its relationship with clinicopathological features and prognosis. Methods: A total of 43 pathological specimens were collected from patients who had undergone a surgery for HCC. Immunohistochemistry(S-P method) was used to determine the expression of CD133 and CD44 proteins, and its relationship with clinical features and prognosis was analyzed. Results: The positive rates of CD133 and CD44 in HCC tissue were 58.1%(25/43) and 69.8%(30/43), respectively, both of which were significantly higher than that in adjacent tissues(P < 0.05).CD133 was closely associated with tumor diameter, degree of tumor differentiation, portal vein tumor thrombosis, and clinical analysis, while CD44 was associated with portal vein tumor thrombosis and clinical stage. Positive expression of both could reduce the 3-year survival rate of patients. Conclusion: The expression of CD133 and CD44 proteins in HCC tissue is higher than that in paracancerous tissues, which is associated with the progression and prognosis of HCC.