痛风清解汤及中药膏外用联合西药治疗急性期痛风性关节炎

Tongfeng Qingjie Decoction and Traditional Chinese Medicine Ointment for External Use Combined with Western Medicine in the Treatment of Acute Gouty Arthritis

目的:研究痛风清解汤及中药膏外用联合西药治疗急性期痛风性关节炎的效果。方法:选取2015年10月至2018年5月汕头市中医医院收治的急性期痛风性关节炎患者100例作为研究对象,按照随机数字表法分为对照组和观察组,每组50例,对照组采用西药常规治疗,于西药常规治疗基础上加用中药痛风清解汤内服和止痛消炎软膏联合红楼膏外敷治疗者作为观察组,回顾性对比分析其症状积分及实验室指标。结果:治疗后,1)观察组症状积分较对照组低,差异有统计学意义(P<0.05);2)观察组血尿酸(UA)是(388.56±100.59)μmol/L,红细胞沉降率(ESR)是(13.22±8.19)mm/h,分别比对照组的(424.92±100.97)μmol/L及(20.20±10.33)mm/h低,差异有统计学意义(P<0.05);3)观察组肿瘤坏死因子(TNF-α)及白细胞介素1β(IL-1β)均比对照组低,差异有统计学意义(P<0.05)。结论:于急性期痛风性关节炎患者中施予痛风清解汤及中药膏外用联合西药治疗可降低症状积分,改善UA、ESR、TNF-α及IL-1β,值得临床推广。

Objective: To study the efficacy of Tongfeng Qingjie Decoction and traditional Chinese medicine(TCM)ointment for external use combined with western medicine in the treatment of acute gouty arthritis. Methods: A total of 100 patients with acute gouty arthritis treated in the Shantou Hospital of Traditional Chinese Medicine from October 2015 to May 2018 were selected as research objects,and divided into a control group and an experimental group according to random number table method,with 50 patients in each group.The group treated by western medicine was regarded as the control group.On the basis of the routine treatment of western medicine,the experimental group was additionally treated with oral Tongfeng Qingjie Decoction orally and Zhitong Xiaoyan Ointment combined with Honglou Ointment for external use.Symptom score and laboratory indexes were analyzed retrospectively and compared. Results: After the treatment,(1)the symptom score in the experimental group was lower than that in the control group,with statistical significance( P <0.05);(2)in the experimental group,the blood uric acid(UA)was(398.56±100.59)μmol/L,and the erythrocyte sedimentation rate(ESR)was(13.22±8.19)mm/h,which were lower than(424.92±100.97)μmol/L and(20.20±10.33)mm/h in the control group respectively,with statistical significance( P <0.05);(3)in the experimental group,the levels of tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were lower than those in the control group,with statistical significance( P <0.05). Conclusion: Tongfeng Qingjie Decoction and TCM ointment combined with western medicine can reduce symptom score and improve UA,ESR,TNF-α and IL-1β in patients with acute gouty arthritis,which is worthy of promotion.