同时性多中心骨肉瘤1例报告及38例国内文献分析

Simultaneous multicentric osteosarcoma:one case report with analysis of 3 cases reported in China

[目的]总结多中心骨肉瘤(MOS)的特点及治疗方式。[方法]对本院收治的1例及近20年国内报道的38例多中心骨肉瘤的临床资料进行回顾性分析。[结果]本病较为罕见,主要多发于青少年。MOS分为同时性MOS和异时性MOS,其中同时性MOS发病率显著多于异时性MOS。该病恶性程度高,预后差,对化疗敏感性低。治疗方案主要是化疗联合手术治疗,但死亡率极高,生存时间短。[结论]尽早的发现并积极的治疗是本病诊治的关键。

[Objective] To summarize the clinical characteristics and treatment strategy of multicentric osteosarcoma (MOS).[Methods] A retrospective study was conducted on 1 patient who was treated in our hospital for MOS and 38 patients who were reported by multiple center in China in recent 20 years.[Results] The MOS is a rare type of osteosarcoma and mainly occurs in the young and adolescent. It may be of a synchronous or metachronous variety, and the synchronous MOS is more com mon than the metachronous MOS. The MOS is highly malignant with poor sensitivity to chemotherapy and regretful prognosis. Despite of combined chemotherapy with surgical treatment, mortality is very high with short survival time.[Conclusion] Early diagnosis and active treatment is the key for this refractory tumor.